SIRT1/DNMT3B-mediated epigenetic gene silencing in response to phytoestrogens in mammary epithelial cells
We performed an integrated analysis of genome-wide DNA methylation and expression datasets in normal cells and healthy animals exposed to polyphenols with estrogenic activity (i.e.phytoestrogens).We identified that phytoestrogens target genes linked to disrupted cellular homeostasis, e.g.genes tenga air-tech regular limiting DNA break repair (RNF16